Catalog Number - 64408-05P

Nova Similars C8™ Octyl is a traditional reversed-phase HPLC stationary phase manufactured on high-purity Type-B spherical silica with a fully endcapped octyl (C8) bonded phase. Designed as a cost-effective alternative to Waters™ Nova-Pak® C8 columns, it offers comparable chromatographic behavior for USP L7 methods while providing the moderate hydrophobic retention and reproducibility expected from a conventional C8 stationary phase. Compared to C18 columns, C8 phases generally provide reduced retention and faster elution of hydrophobic analytes.

64408-05P is a 50 mm x 4.6 mm ID analytical column packed with 4 µm Nova Similars C8 particles. The short 50 mm length is optimized for rapid analyses, fast equilibration, and high-throughput workflows. The 4 µm particle size provides improved efficiency and somewhat sharper peaks than comparable 5 µm packings while maintaining moderate operating pressure on conventional HPLC systems. Typical operating flow rates are approximately 1.0–2.0 mL/min.

This USP L7 column is ideal for hydrophobic and neutral compounds when less retention is desired than a comparable C18 phase. Common applications include pharmaceutical analysis, long-chain fatty acid separations, quality control testing, and fast analytical methods requiring chromatographic behavior similar to Waters™ Nova-Pak® C8 columns.

Key Benefits

• Type-B spherical silica stationary phase

• Suitable alternative for USP L7 methods

• Comparable selectivity to Waters™ Nova-Pak® C8 columns

• Fast analysis with 50 mm column length

• Higher efficiency than comparable 5 µm columns

• Lower retention than C18 columns

• Excellent for hydrophobic and neutral compounds

• End-capped C8 bonded phase

Typical Applications

• USP L7 methods

• Reversed-phase HPLC

• Pharmaceutical analysis

• Quality control testing

• Method development

• Long-chain fatty acid analysis

• Fast analytical separations

• Method transfer and validation

Specifications

• Product Type: HPLC Column

• Stationary Phase: Nova Similars C8 Octyl

• USP Classification: L7

• Particle Size: 4 µm

• Particle Type: Type-B Spherical Silica

• Bonded Phase: C8 (Octyl)

• Endcapped: Yes

• Column Dimensions: 4.6 mm ID x 50 mm

• Length: 50 mm

• Recommended Flow Rate: 1.0–2.0 mL/min

• Brand: Cogent

Important Notes

• Designed for reversed-phase chromatography

• Short column length provides rapid analyses

• Higher efficiency than comparable 5 µm columns

• Moderate operating pressure on conventional HPLC systems

• Provides less retention than comparable C18 stationary phases

• Excellent alternative for many USP L7 methods

• Suitable for high-throughput workflows

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